Hum Psychopharmacol: ADHD, Bupropion vs methylphenidate

Ranked #1 during August 2012Bupropion versus methylphenidate in the treatment of children with attention-deficit/hyperactivity disorder: randomized double-blind study.

Study design & execution: A 6 week, randomized, double blinded, parallel design. Elements of the trial design are clearly detailed (as per the CONSORT statement) in Methods section of the text.

The study's primary outcome variable remains consistent from the registry to the top-line result:

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Acta Psychiatr Scand: Bipolar depression, lamotrigine vs lamotrigine+divalproex

Ranked #1 during July 2012Lamotrigine vs. lamotrigine plus divalproex in randomized,  placebo-controlled maintenance treatment for bipolar depression.

Study design & execution: A two arm, randomized, double-blind, parallel study to compare Lamotrigine against a combination of Lamotrigine + Divalproex as a maintenance treatment for patents with bipolar depression.

The text is not entirely clear what the study's specific primary objective and its associated primary outcome variable was:

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J Atten Disorders: Adult ADHD, duloxetive vs placebo

Ranked #1 during June 2012: Duloxetine in Adults With ADHD: A Randomized, Placebo-Controlled Pilot Study.

Study design & execution: A 6 week parallel design RCT pilot study involving 30 adult patients with a diagnosis of ADHD to investigate the treatment potential of duloxetine. The Introduction section spells out the overarching aim of the trial:

The aim of the present pilot study was...Read the rest of this entry »

BMC Psychiatry: Adult ADHD, dex+CBT vs placebo+CBT

Ranked #1 during May 2012A Randomized Controlled Trial of CBT Therapy for Adults with ADHD with and without Medication.

Study design & execution: A subset of data from a previous study is taken to compare stimulants with placebo in adult patients with ADHD all of whom receive cognitive based therapy (CBT). The study objective is spelt out as follows:

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